Inside CGRP Inhibitors & Migraine Prevention
With a series of calcitonin gene-related peptide antagonists that promise to prevent migraine now emerging from regulatory review, anticipation is growing across the healthcare and patient community. What can clinicians expect from this new class of monoclonal antibodies?
Calcitonin gene-related peptide (CGRP) is a vasoactive peptide. It is part of the “inflammatory soup” that is involved in dilation of cerebral and dural blood vessels. Widely distributed throughout the body, CGRP levels in serum increase during migraine or cluster headache. Triptans provide some migraine relief by modulating the CGRP.